TP53 codon 72 polymorphism as a risk factor for cardiovascular disease in a Brazilian population
نویسندگان
چکیده
منابع مشابه
TP53 codon 72 polymorphism and risk of acute leukemia.
TP53 is the mostly commonly mutated gene in many cancers and the P53 tumor suppressor protein is involved in multiple cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control and apoptosis. A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine. TP53 Ar...
متن کاملTP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia.
UNLABELLED Defects in the tumor suppressor gene TP53 are known to be important in chronic lymphocytic leukemia (CLL) and TP53 inactivation is associated with a particularly aggressive form of the disease. The single nucleotide polymorphism in the TP53 gene at codon 72 (rs1042522), results in amino acid substitution influencing apoptotic potential of TP53 protein. The aim of the study was to eva...
متن کاملTP53 codon 72 polymorphism in adult soft tissue sarcomas.
Soft tissue sarcomas (STS) are tumors of mesodermal origin, comprising about 1% of all adult neoplasms. Management of such tumors is an important medical challenge. TP53 codon 72 polymorphism results in either the arginine or proline form of the p53 protein; several studies have investigated whether codon 72 polymorphisms are risk and prognostic factors for cancer. We investigated p53 codon 72 ...
متن کاملThe Role of TP53 Gene Codon 72 Polymorphism in Leukemia
The purpose of this meta-analysis was aimed to evaluate the association of tumor protein p53 (TP53) gene codon 72 polymorphism with leukemia susceptibility. We searched PubMed to identify relevant studies, and 16 case-control studies from 14 published articles were identified as eligible studies, including 2062 leukemia patients and 5826 controls. After extracting data, odds ratio (OR) with the...
متن کاملAssociation of the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis
This study was conducted in order to investigate the implications of the R72P polymorphism in the TP53 gene in breast cancer risk. The enlightenment of this matter might provide a piece of information about the potential implications of this polymorphism in patient risk. A meta-analysis was conducted considering a large sample size from studies with conflicting results on the R72P polymorphism ...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 2007
ISSN: 1414-431X
DOI: 10.1590/s0100-879x2006005000174